Gigapixel micro-camera array microscope

Capturing video with gigapixel-sized frames using nearly 100 lenses and sensors

More information about this new technology may be found at https://www.ramonaoptics.com/

Associated paper: 

E. Thomson et al., "Gigapixel behavioral and neural activity imaging with a novel multi-camera array microscope," In Submission (pre-print on bioRxiv, 2021)

Associated project page: mcam.deepimaging.io

Please check out out gigapixel video viewer as well!

High-throughput optical microscopy is currently transforming the research fields of genetics, drug discovery and neuroscience. Due to challenges with large lens design, standard microscopes have a hard time capturing anything more than 50 megapixels per image snapshot, which makes it impossible to simultaneously image at cellular-resolution over a multi-centimeter viewing area (field of view, FOV). To enable cellular resolution imaging over fields of view 10s of cm in diameter, we are utilizing an array of miniaturized cameras, tiled in a 12x8 configuration and collectively called the micro-camera array microscope (MCAM).

mcam_pic

 

Each camera is individually addressable and controllable to enable rapid acquisition over the fields of view as large as 20cm in diameter, providing us with gigapixel-scale snapshot images. Preliminary applications for the MCAM are being developed for behavioral imaging of freely swimming zebrafish larvae. This work is in collaboration with Ramona Optics, Prof. Eva Naumann in the Duke School of Medicine, Dr. Tim Dunn in Duke Statistical Science, and a number of other important collaborators!

Please check out some of our new gigapixel videos at our online interface here: gigazoom.rc.duke.edu  

mcam_demo

 

If you are interested in our extreme wide-field-of-view microscope and think you have an interesting application for us, please feel free to get in touch!